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ORIGINAL ARTICLE
Year : 2014  |  Volume : 1  |  Issue : 2  |  Page : 58-61

Profile of glucose intolerance in HIV-positive patients on 1 st line and 2 nd line antiretroviral therapy


1 Department of Medicine, Manipal Hospital, Bangalore, Karnataka, India
2 Department of Medicine, Regional Institute of Medical Science, Imphal, Manipur, India
3 Department of Pharmacology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India

Correspondence Address:
Asha Basavareddy
Department of Pharmacology, Sri Devaraj Urs Medical College, Tamak, Kolar - 563 101, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2225-6482.147659

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Background and Aims: Human Immunodeficiency Virus infections have developed into a global pandemic with cases reported from virtually every country. Manipur has also shown an increase in the incidence of HIV/AIDS since the past decade. Thus far, very little data is available in this part of the country about the effect of 1 st and 2 nd line antiretroviral therapy (ART) on the glycemic status of the patients. Hence, this study was undertaken to assess and compare the effect of 1 st line and 2 nd line ART on glycemic status of HIV patients. Subjects and Methods: The study was carried out in the ART centre in Regional Institute of Medical Sciences, Imphal. It was a cross-sectional comparative observational study carried out from October 2010 to September 2012. A total of 292 patients were included in the study, of which 211 patients were receiving ART 1 st line and 81 patients receiving ART 2 nd line. HIV patients receiving ART were investigated for fasting, 2 hours post-prandial glucose, CD4 cell count, total cholesterol, and serum triglyceride levels. Chi-square and Student's t tests were used to find the significance between the two groups. Pearson's correlation between clinical variable and sugar and lipid parameters was performed to find the effect of relationship. Results: The difference between the two groups was statistically significant in Random Blood Sugar (RBS), Fasting Blood Sugar (FBS) and Post Prandial Blood sugar (PPBS) values (P = 0.022; P = 0.004 and P < 0.001 respectively). Patients in Group II had significantly higher values of TC and TG compared to Group I patients with a P value of <0.001. Conclusions: The glucose and lipid parameters were significantly high receiving ART 2 nd line patients in comparison with ART 1 st line patients.


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